Mechanical behaviour with temperatures of aluminum matrix composites with CNTs

Aluminum is a very useful structural metal employed in different industrial sectors, in particular it is used in large quantities in automotive, aeronautic and nautical industries. The main reasons of its wide use are: a very good oxidation resistance, excellent ductility, low melting temperature (660 °C) and low density (2.71 g/cm3). However, in order to reduce the emissions and fuel consumption is necessary to reduce the overall weight of vehicles by increasing mechanical properties of the structural material. The improvement of mechanical properties is normally achieved through use of reinforcement in materials, used like matrix, in order to improve some specific characteristics. In this work composites of carbon nanotubes (CNTs) dispersed in aluminum were made. The most difficulties in the preparation of this type of composite are represented by the low wettability between metallic matrix and fillers and the possibility of the oxidation of metal during melting with consequent decreasing of mechanical proprieties. The composite was obtained by three consecutive step: the first one is the functionalization of fillers surface to improve the fillers dispersion, the second one is the dispersion of fillers in the matrix by powder mixing and the third one is the melting and casting of the mix prepared. In particular, fillers used are multi walled carbon nanotubes (MWCNTs) with functionalized surface by treatment with a solfonitric solution. Melting and casting are carried out with the aid of an induction furnace with a controlled atmosphere system and centrifugal casting. Argon is the inert gas used to prevent the oxidation of aluminium during fusion. Young’s modulus was evaluated at different temperature and correlated with the different CNTs percentage. The dispersion rate of fillers and the microstructure of the sample were evaluated by FESEM micrograph

The Effect of Hot Gas in WMAP's First Year Data

By cross-correlating templates constructed from the 2 Micron All Sky Survey (2MASS) Extended Source (XSC) catalogue with WMAP's first year data, we search for the thermal Sunyaev-Zel'dovich signature induced by hot gas in the local Universe. Assuming that galaxies trace the distribution of hot gas, we select regions on the sky with the largest projected density of galaxies. Under conservative assumptions on the amplitude of foreground residuals, we find a temperature decrement of -35 $\pm$ 7 $\mu$K ($\sim 5\sigma$ detection level, the highest reported so far) in the $\sim$ 26 square degrees of the sky containing the largest number of galaxies per solid angle. We show that most of the reported signal is caused by known galaxy clusters which, when convolved with the average beam of the WMAP W band channel, subtend a typical angular size of 20--30 arcmins. Finally, after removing from our analyses all pixels associated with known optical and X-ray galaxy clusters, we still find a tSZ decrement of -96 $\pm$ 37 $\mu$K in pixels subtending about $\sim$ 0.8 square degrees on the sky. Most of this signal is coming from five different cluster candidates in the Zone of Avoidance (ZoA), present in the Clusters In the ZoA (CIZA) catalogue. We found no evidence that structures less bound than clusters contribute to the tSZ signal present in the WMAP data.Comment: 10 pages, 4 figures, matches accepted version in ApJ Letter

An analytic strategy for data processing of multimode networks

Complex network data structures are considered to capture the richness of social phenomena and real-life data settings. Multipartite networks are an example in which various scenarios are represented by different types of relations, actors, or modes. Within this context, the present contribution aims at discussing an analytic strategy for simplifying multipartite networks in which different sets of nodes are linked. By considering the connection of multimode networks and hypergraphs as theoretical concepts, a three-step procedure is introduced to simplify, normalize, and filter network data structures. Thus, a model-based approach is introduced for derived bipartite weighted networks in order to extract statistically significant links. The usefulness of the strategy is demonstrated in handling two application fields, that is, intranational student mobility in higher education and research collaboration in European framework programs. Finally, both examples are explored using community detection algorithms to determine the presence of groups by mixing up different modes

Long-term variability of CO2 and O in the Mars upper atmosphere from MRO radio science data

We estimate the annual variability of CO2 and O partial density using approximately 6years of Mars Reconnaissance Orbiter (MRO) radio science data from August 2006 to January 2012, which cover three full Martian years (from the northern hemisphere summer of 28 to the northern hemisphere summer of 31). These two elements are the dominant species at the MRO periapsis altitude, constituting about 70-80% of the total density. We report the recovered annual cycle of CO2 and the annual and seasonal cycle of O in the upper atmosphere. Although no other observations are available at those altitudes, our results are in good agreement with the density measurements of the Mars Express Spectroscopy for Investigation of Characteristics of the Atmosphere of Mars, which uses stellar occultations between 60 and 130km to determine the CO2 variability, and with the Mars Global Reference Atmospheric Model 2010 for the O annual and seasonal variabilities. Furthermore, the updated model provides more reasonable MRO drag coefficients (CD), which are estimated to absorb mismodeling in the atmospheric density prediction. The higher content of dust in the atmosphere due to dust storms increases the density, so the CDs should compensate for this effect. The correlation between the drag coefficient and the dust optical depth, measured by the Mars Odyssey Thermal Emission Imaging System (THEMIS) instrument, increases from 0.4 to 0.8 with the a priori and adjusted models, respectively. The trend of CDs not only confirms a substantial improvement in the prediction of the atmospheric density with the updated model but also provides useful information for local dust storms, near MRO periapsis, that cannot be measured by the opacity level since THEMIS does not always sample the southern hemisphere evenly

The ALADIN Interactive Sky Atlas

The Aladin interactive sky atlas, developed at CDS, is a service providing simultaneous access to digitized images of the sky, astronomical catalogues, and databases. The driving motivation is to facilitate direct, visual comparison of observational data at any wavelength with images of the optical sky, and with reference catalogues. The set of available sky images consists of the STScI Digitized Sky Surveys, completed with high resolution images of crowded regions scanned at the MAMA facility in Paris. A Java WWW interface to the system is available at: http://aladin.u-strasbg.fr/Comment: 8 pages, 3 Postscript figures; to be published in A&

Use of Eribulin mesylate as second-line therapy in elderly patients with HER/2 negative metastatic breast cancer (MBC): Efficacy, tolerability and Quality of Life

OBJECTIVE: Eribulin mesylate (Halaven®) is a non-taxane inhibitor of microtubule indicated as monotherapy in patients with metastatic breast cancer (MBC), which progresses after anthracycline and taxanes therapy. In this retrospective observational study, we want to evaluate the efficacy of Eribulin in elderly women with MBC pretreated with anthracyclines and taxanes. PATIENTS AND METHODS: 40 elderly patients > 70 years of age were enrolled, and the median age was 76 years (range 70-82). Overall survival (OS), Progression Free Survival (PFS), Objective Response Rate (ORR) were primary endpoints, tolerability, carcinoembryonic antigen levels 15.3 (Ca 15.3), before and after treatment, and Quality of Life (QoL) were secondary endpoints. RESULTS: Eribulin treatment was well tolerated, produced a good level of disease control, a manageable toxicity profile and a significant impact on QoL. Median OS was 12.8 months and median PFS was 3.2 months. A significant correlation was observed between reduction of Ca 15.3 and PFS with a value of 0.59 (p = 0.002). CONCLUSIONS: Despite a limited number of patients and a modest manageable toxicity, Eribulin is a chemotherapy treatment that has showed to be an effective and well-tolerated therapeutic option in elderly patients with MBC. Further analysis should focus on the elderly patients in our setting of study

Functional Analysis of Cdc42 in Actin Filament Assembly, Epithelial Morphogenesis, and Cell Signaling during Drosophila Development

AbstractCdc42, a member of the Rho family of GTP binding proteins, functions in the formation of polarized actin structures, in elongation of cell shape, and in cell signaling. Although genetic mutations previously have not been available in multicellular organisms, studies have attempted to discern Cdc42 functions in organisms, including Drosophila, using dominant active or interfering alleles. Here, for the first time, we examine the functions of Cdc42 in developing tissues using loss-of-function mutations in the Drosophila Cdc42 gene. We find that Cdc42− epithelial cells fail to elongate into a columnar cell shape and cannot maintain a monolayered epithelial structure. In contrast to previous studies, we find no requirement for Cdc42 in cell division or in activation of the Jun N-terminal kinase pathway. In addition, Cdc42 function is not required for cytoplasmic actin filament assembly in the nurse cells during oogenesis, although it may facilitate this process. Furthermore, our results indicate that Cdc42 plays a role in intercellular interactions between the germ line and the somatic follicle cells. These results confirm the role of Cdc42 in actin filament assembly and provide new insights into its functions in epithelial morphogenesis and regulating intercellular signaling events

GASTRIC METASTASES ORIGINATING FROM OCCULT BREAST LOBULAR CARCINOMA: DIAGNOSTIC AND THERAPEUTIC PROBLEMS

BACKGROUND: Breast cancer is the most frequent malignant tumour to metastasize into the gastrointestinal tract in female and is second only to malignant melanoma. Nevertheless gastrointestinal metastases arising from breast cancer are quite rare. The upper gastrointestinal tract is more frequently involved and lobular infiltrating carcinoma has a greater predilection compared to the ductal type. CASE PRESENTATION: The authors describe the case of a 70 years old woman with a preoperative diagnosis of gastric undifferentiated medullary--type carcinoma, which was the first manifestation of an occult breast carcinoma. The primary site of carcinoma was identified with the use of a panel of selected immunohistochemical markers. CONCLUSION: Our goal in this case report is to increase the awareness of surgeons and clinicians to rule out the possibility of mammary origin in circumstance of gastric cancer occurring in female, even in patients without a previous or concurrent history of breast carcinoma. Although not a particularly common event, it is, nevertheless, reported in the literature. The differentiation between primary gastric carcinoma and metastatic breast carcinoma is essential for planning the correct therapeutic approach, in order to avoid the patient unnecessary surgery